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Journal international du développement et de la recherche sur les médicaments

  • ISSN: 0975-9344
  • Indice h du journal: 44
  • Note de citation du journal: 59.93
  • Facteur d’impact du journal: 48.80
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Abstrait

Synthesis, Characterization, and Antibacterial Activity two New Schiff Bases devired from (E)-2-(((2-aminoethyl) imino) methyl) phenol (E)-2-(4-aminobut-1-enyl)-5-methylbenzamine

Sheheryar* and Mohib Ullah Shah

In this study two new Schiff base ligands were synthesized, characterized and antibacterial activities were investigated against Escherichia coli, Pseudomonas aeruginosa, Bacillus cereus, Salmonella typhimurium, and Staphylococcus aureus. (E)-2-(4-aminobut-1-enyl) phenol derived from Ethylene diamine and Salicyldehye. (E)-2-(4-aminobut-1-enyl)-5-methylaniline derived from 4-dimethyl amino benzaldehyde and Ethylene di-amine. The Schiff bases were characterized by elemental analysis and FT-IR. The Schiff base ligands were screened in vitro for their antibacterial inhibiting potential by using Disc diffusion method. The results indicated that the Schiff base I have showed biological activity against E coli. The main purpose of the study was to compare the inhibitory effect of these Schiff bases with commercial antibiotics Ciprofloxacin and Erythromycin to introduce new varieties of antibacterial agents.

Keywords

Schiff base; Antibacterial; FT-IR; Chemical synthesis