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Journal international du développement et de la recherche sur les médicaments

  • ISSN: 0975-9344
  • Indice h du journal: 44
  • Note de citation du journal: 59.93
  • Facteur d’impact du journal: 48.80
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Abstrait

Synthesis and Toxicity of Complexes of Cu(II), Co(II) and Mn(II) with a 2(4-nitrophenyl)-4.5-diphenyl-1H-immidazole Ligand

Fahimah Martak, Wahyu Prasetyo Utomo, Zjahra Vianita Nugraheni, Arynta Dharmayanti, Rose Malina Annuur, Shinta Dwitifani Risqizia Poetri and Mohd Tajudin Mohd Ali

Copper(II), cobalt(II), and manganese(II) complexes with 2(4-nitrophenyl)-4.5-diphenyl-1H-imidazole ligand have been successfully synthesized. The molecular formula for the formed complex compounds are [Cu(2(4-nitrophenyl)-4.5-diphenyl-1H-imidazole)2], [Co(2(4- nitrophenyl)-4.5-diphenyl-1H-imidazole)3] and [Mn(2(4-nitrophenyl)-4.5-diphenyl-1H-imidazole)3] complexes. This was confirmed by the results of the characterization of the CHN analyzer and AAS spectrometry. The FTIR characterization showed the presence of a distinct vibration spectrum of Cu-O, Co-O and Mn-O. Toxicity tests of the complex compounds [Cu(2(4-nitrophenyl)-4.5-diphenyl-1H-imidazole)2], [Co(2(4-nitrophenyl)-4.5- diphenyl-1H-imidazole)3] and [Mn(2(4-nitrophenyl)-4.5-diphenyl-1H-imidazole)3] was done with BSLT method and showed the LC50 values of 229.66 ppm; 265.79 ppm; 182.79 ppm meaning that [Mn(2(4-nitrophenyl)-4.5-diphenyl-1H-imidazole)3] is toxic compound.