Guoqiang Zhang
Avian meningitis Escherichia coli(E. coli) can beget acute bacterial meningitis which threatens flesh health, causes great profitable losses in the flesh assiduity, and has lately been suspected as a implicit zoonotic pathogen. Melatonin can offset bacterial meningitis- convinced dislocation of the blood – brain hedge( BBB), neuroinflammation, and reduce mortality. There are adding data showing that melatonin’s salutary goods on bacterial meningitis are associated with intestinal microbiota. In this study, our data showed that melatonin soothed neurological symptoms, enhanced survival rate, defended the integrity of the BBB, reduced the bacterial cargo in colorful apkins and blood, and inhibited inflammation and neutrophil infiltration of brain towel in an APEC TW- XM- meningitis mice model. The results of 16S rRNA showed that melatonin pretreatment significantly maintained the composition of intestinal microbiota in APEC- meningitis mice. The cornucopia and diversity of intestinal microbiota were disturbed in APEC TW- XM- meningitis mice, with a dropped rate of Firmicutes to Bacteroides and an increased the cornucopia of Proteobacteria. Melatonin pretreatment could significantly ameliorate the composition and cornucopia of dangerous bacteria and palliate the dropped cornucopia of salutary bacteria. Importantly, melatonin failed to affect the meningitis neurologic symptoms caused by APEC TW- XM infection in antibioticpretreated mice. In conclusion, the results suggest that melatonin can effectively help meningitis convinced by APEC TW- XM infection in mice, depending on the intestinal microbiota. This finding is helpful to further explore the specific target medium of melatoninintermediated intestinal microbiota in the forestallment of and protection against Escherichia coli meningitis.
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