Mustafa Ibrahim Oladayo*, Yusuf Tanko, Rasheed Yusuf, Sunday Abraham Musa
The study looked into the correlation between glycated haemoglobin A1c (HbA1c) and the risk of developing diabetic nephropathy among diabetic patients attending Ahmadu Bello University Teaching Hospital Zaria, Nigeria, and also determined the level of HbA1c where the risk of nephropathy becomes pronounced.One hundred and one (101) diabetic patients were used for the study comprising of both male and female patients. About 5mL of blood sample was collected from each of the subjects after about 10 hours of overnight fasting. Then 3mL of the sample was centrifuged and the serum analysed for serum creatinine and also fasting blood glucose (FBG). The Glomerular Filtration Rate (GFR) was then calculated from the serum creatinine value using the Cockroft-Gault equation.The remaining 2mL from the blood sample was transferred into EDTA bottles and analysed immediately for glycated haemoglobin (HbA1C).Thirty-seven (37) of the diabetic subjects had mean HbA1C level of 6.96% that correspond to mean FBG level of 91.37mg/dL. Initially no significant correlation was found between HbA1c and the GFR. But there was significant correlation between HbA1c and GFR among patients with HbA1c level ≥ 9% (R= -0.35). Patients with this level of HbA1c (≥ 9%) had equivalent FBG ≥ 136 mg/dL.he risk of developing renal complications among patients was only prominent at the level of 9% HbA1c and above, and monitoring of patients should be done accordingly in order to guard against overtreatment, hypoglycaemia and unnecessary expenses.
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