English Spanish Chinese Russian German Japanese Portuguese Hindi Telugu Tamil

Journal international du développement et de la recherche sur les médicaments

  • ISSN: 0975-9344
  • Indice h du journal: 44
  • Note de citation du journal: 59.93
  • Facteur d’impact du journal: 48.80
Indexé dans
  • Genamics JournalSeek
  • Infrastructure nationale des connaissances en Chine (CNKI)
  • CiteFactor
  • Scimago
  • Répertoire d'indexation des revues de recherche (DRJI)
  • OCLC - WorldCat
  • Publions
  • MIAR
  • Commission des bourses universitaires
  • Pub européen
  • Google Scholar
  • SHERPA ROMÉO
  • Laboratoires secrets des moteurs de recherche
  • ResearchGate
Voir plus
Partager cette page

Abstrait

Development and Validation of HPLC Methods for the Determination of Propranolol Hydrochloride and Hydrochlorothiazide Related Substances in Combination Tablets

Xiaolei Tang, Yuanyuan Cao, Jiaqian Yu, Runjie Shi, Yuye Huang, Jinhui Wu and Yiqiao Hu

A recent study shows that propranolol hydrochloride (PRO) related substances may also reduce the stability of tablets in storage. Therefore, it is necessary to control the level of PRO related substances in tablets. However, the analysis in U.S. pharmacopoeia could not detect PRO related substances. To overcome this, we developed a new method which can detect PRO, hydrochlorothiazide (HCT) and all of their impurities. In this study, validation studies were also performed, linear relationship with a good correlation coefficient (r2)>0.990 was found of both PRO impurities and HCT impurities in the range of 0.12-0.60, and 0.15-0.75 μg/ml respectively. Acceptable intra- and inter- assay precisions were achieved. Accuracy and robustness were reported as percent recovery, and all the recoveries were at the range of 70-130%. After validation, the methods were successfully used in the routine quality control of the tablets.

Avertissement: Ce résumé a été traduit à l'aide d'outils d'intelligence artificielle et n'a pas encore été examiné ni vérifié