Emmanuel Ifeanyi Obeagu*, Emmanuel Muhimbura, Byamungu Pahari Kagenderezo, Onyekachi Splendid Uwakwe, Sarah Nakyeyune and Getrude Uzoma Obeagu
Sickle cell disease has been described by many scholars as a chronic inflammatory disease which is linked to many factors such as endothelial destruction, increased synthesis of reactive oxygen specie, haemolysis, increased synthesis of pro inflammatory cytokines among others. Inflammatory process play a major function in the activation of acute painful vaso-occlusion crisis that forms the main reason for the hospitalization of patients with sickle cell anaemia. Inflammatory processes, are key components of several complications of the disease including autosplenectomy, acute chest syndrome, pulmonary hypertension, leg ulcer, nephropathy and stroke and also ultimately initiates painful vaso-occlusion episodes that characterize Sickle Cell Disease. This study titled “Update on Interferon Gamma and C Reactive Proteins in Sickle Cell Anaemia in Crises, aims at finding out the recent updates on interferon gamma; a pro-inflammatory cytokine that plays a central role in inflammation and auto-immunity, and CRP; an acute phase protein used as a marker of inflammation in sickle cell anaemia patients in crisis. A lot of search engines were consulted in the course of writing this review such as scopus, Pubmed Central, Web of Science, Semantics, Google Scholar, Researchgate, Academia Edu, etc. Previous studies have suggested that levels of pro-inflammatory cytokines vary between steady-state and crisis states in SCA patients, hypothesized to help monitor clinical progression of the disease. . Newer therapies that target pathways downstream of the sickle are considered better options. This knowledge may have implications for the development of new treatments for sickle cell disease.
KeywordsSickle cell anaemia, Crisis, Interferon-gamma, C - reactive protein, Inflammatory cytokines, Cytokines
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