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Enzymologie moléculaire et cibles médicamenteuses

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Abstrait

A Note on Purine Analogues with Electronic Absorption in the Visible Region.

Andrzej Rykowski

The absorption spectrum of some 5-substituted derivatives was found to extend to the visible region. These compounds were found to inhibit some enzymes of purine metabolism, like xanthine oxidase or bacterial purine-nucleoside phosphorylase with Ki values in the 10-3 –10-5 M range.

Keywords

Thiazine; Purine analogues; Enzyme inhibitors; Spectroscopic probes.